To better understand the impact of COVID-19 and physical and social distancing measures on the lifestyle and mental health of immunosuppressed individuals and their loved ones, data were collected through two online questionnaires: a first questionnaire between May and August 2020 and a second follow-up questionnaire between May and September 2021. In this summary report, we present preliminary results from the 2021 follow-up questionnaire and the comparison with the 2020 data. We present an overview of the data regarding the profile of participants, the impact of COVID-19 on mental health, and how these impacts vary by pet ownership.